Fructose-1,6-diphosphate Sodium Salt

Molecular Formula: C6H14O12P2
CAS Number: 41012-14-0
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Is an intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is generated by the phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction, mediated by fructose-1,6-bisphosphatase-1, is one of the rate-limiting steps in gluconeogenesis.1,2 The same reaction occurs within chloroplasts in plants as part of the reductive pentose phosphate cycle.3Because cancer cells adopt glycolysis as a major source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.