Thiostrepton

Molecular Formula: C72H85N19O18S5
CAS Number: 1393-48-2
Appearance: White to off-white powder

Thiostrepton is a natural cyclic oligopeptide antibiotic. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1.